The enzyme involved in the activation for fatty acids beta oxidation is?
Correct Answer: Thiokinase
Description: Fatty acids must first be conveed to an active intermediate before oxidation. This is the only step in the oxidation of a fatty acid that requires energy from ATP. In the presence of ATP and coenzyme A, the enzyme acyl-CoA synthetase (thiokinase) catalyzes the conversion of fatty acid (or FFA) to an "active fatty acid" or acyl-CoA, using one high-energy phosphate and forming AMP and PPi. The PPi is hydrolyzed by inorganic pyrophosphatase with the loss of a fuher high-energy phosphate, ensuring that the overall reaction goes to completion. Acyl-CoA synthetases are found in the endoplasmic reticulum, peroxisomes, and on the outer membrane of mitochondria.
Category:
Biochemistry
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