Which of the following does not describe a documented mechanism of tumor-mediated immune evasion?
Correct Answer: Antigenic variation
Description: Tumor cells have evolved mechanisms to escape and evade immune recognition. These mechanisms include various molecular genetic processes of eliminating MHC I from the tumor cell surface. Mutations inhibit efficient antigen processing and presentation. Tumor cells also block immune cells by secretion of suppressor proteins, most commonly TGF-b1, and other cytokine like "decoy" molecules to confuse the immune system. Antigenic variation is an immune escape mechanism ascribed to pathogenic microbes such as viruses for example.
Category:
Microbiology
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