All of the following are true about nodular sclerosis of Hodgkin’s disease except –
Correct Answer: CD 20 +
Description: CD 20 is positive in lymphocytic predominance variant (not in nodular sclerosis variant)
Pathology of nodular sclerosing variant
Presence of lacunar variant of Reed-sternberg cells.
Deposition of collagen in bands that divide the involved lymph nodes into circumscribed nodules.
Fibrosis may be scant or abundant.
The Reed-Sternberg cells are found in a polymorphous background of T-cells, eosinophils, plasma cells and macrophages.
Following information has been added in 8th of Robbins
Classical Reed-Sternberg cells are also positive for PAX5 (a B-cell transcription factor) along with CD15 and CD30.
Category:
Pathology
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