Granisetron, has antiemetic properties because of:
Correct Answer: Serotonin receptor-blocking action
Description: Granisetron is 5-HT3 antagonist and is 10 times more potent than ondansetron, and probably more effective during the repeat cycle of chemotherapy. The weak 5-HT4 blockade seen with ondansetron has not been detected in granisetron. lts plasma t½ is longer (8-12 hrs) and it needs to be given only twice on the day of chemotherapy.
Category:
Pharmacology
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