A 33-year-old man is diagnosed with essential hypeension. He is staed on a blood pressure medication, and after 6 weeks, he notes fatigue, rash over his face, joint aches, and effusions. A serum antinuclear antibody (ANA) test is positive. Wof is the most likely agent
Correct Answer: Hydralazine
Description: VASODILATORS Hydralazine/Dihydralazine Adverse effects:- are frequent and mainly due to vasodilatation. * Facial flushing, conjunctival injection, throbbing headache, dizziness, palpitation, nasal stuffiness, fluid retention, edema, CHF. * Angina and MI may be precipitated in patients with coronary aery disease. * Postural hypotension is not prominent because of little action on veins: venous return and c.o. are not reduced. * Paresthesias, tremor, muscle cramps, rarely peripheral neuritis. * Lupus erythematosus or rheumatoid ahritis like symptoms develop on prolonged use of doses above 100 mg/day. This is more common in women and in slow acetylators. Ref:- kd tripathi; pg num:-567
Category:
Pharmacology
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