Which among the following is FALSE about congenital toxoplasmosis?
Correct Answer: IgG is diagnostic
Description: Negative IgM with positive IgG indicates past infection. The presence of IgM antibody (which does not cross placenta) in the infant's circulation will diagnose congenital toxoplasmosis. The double sandwich IgA-ELISA is more sensitive than the IgM-ELISA for detecting congenital infection in the fetus and newborn. The methods used to detect IgM are 1)Double sandwich IgM ELISA 2)IgM immunosorbent assay. Ref: Kim K., Kasper L.H. (2012). Chapter 214. Toxoplasma Infections. In D.L. Longo, A.S. Fauci, D.L. Kasper, S.L. Hauser, J.L. Jameson, J. Loscalzo (Eds), Harrison's Principles of Internal Medicine, 18e.
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