False about Aliskiren is:
Correct Answer: It is p-glycoprotein inhibitor
Description: Aliskiren: MOA: Potent competitive inhibitor of renin. Binds the active site of renin and blocks conversion of angiotensinogen to Angiotensin I. Pk: Bioavailability of aliskiren is low but still used orally as it has high affinity and potency. It is a substrate for P- glycoprotein (Not the inhibitor). It can cause hyperkalemia by inhibiting the RAAS through which K+ is removed from the body. It is well tolerated in: Elderly population. Hepatic disease and renal insufficiency patients. Type 2 diabetes patients.
Category:
Pharmacology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now