A child presents with hematuria and nephrotic syndrome. A diagnosis of minimal change disease was made. Which of the following statements about the diagnosis is true:
Correct Answer: Glomerular function is lost due to loss of polyanions around the foot processes
Description: Answer is A (Glomerular function is lost due to loss of polyanions around the foot processes) Loss of polyanionic charge is believed to be the main cause for loss of glomerular function (albuminuria) in minimal change disease Loss of polyanions is believed to result in effacement offoot processes and development of proteinuria in minimal change disease Mechanism of Proteinuria in Minimal change Disease (MCD) (Heptinstall's) Effacement of foot process (Earlier called fusion of foot process) is believed to play an impoant role in causes proteinuria in MCD. The mechanisms responsible for fusion /effacement of foot processes include: Loss of negative charge (Loss of Polyanions) Disruption of components of slit diaphragm (Demonstrated in congenital nephrotic syndrome of the Finnish type) Loss of actin cytoskeleton Detachment of the podocyte from the GBM. Note : Minimal change disease is characterized by diffuse effacement offoot process 'diffuse effacement offoot process is synonymous with fusion offoot processes.
Category:
Medicine
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now