Following is not true about the gene mutations leading to breast carcinoma?

A. Most common mutation in inherited breast carcinoma is BRCA 1

B. BRCA 1 mutation is present in most of the cases of breast carcinoma

C. Inherited breast carcinomas make about 3 % of the total cases

D. p53 mutation also increases chances of colon and brain cancer

Correct Answer: BRCA 1 mutation is present in most of the cases of breast carcinoma

Description: Ans. is 'b' i.e., BRCA 1 mutation is present in most of the cases of breast carcinomaGenetic mutations associated with breast cancer are of two types -i) Germline mutations (inherited mutations)Involved in familial cases of breast cancer.ii) Somatic mutations (acquired mutation)Involved in sporadic cases of breast cancer

Category: Pathology

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