Drugs used in the treatment of pruritus in PBC?
Correct Answer: All of the above
Description: The main symptoms of PBC are fatigue and pruritus, and symptom management is impoant.Several therapies have been tried for treatment of fatigue, but none of them have been successful; frequent naps should be encouraged. Pruritus is treated with antihistamines, narcotic receptor antagonists (naltrexone), and rifampin. Cholestyramine, a bile salt-sequestering agent, has been helpful. Plasmapheresis has been used rarely in patients with severe intractable pruritus.Ref: Harrison&;s Principles of Internal Medicine; 19th edition; Chapter 365; Cirrhosis and Its Complications Page no: 2061
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