Von willebrands disease all are true except – a) Factor VIII C deficiencyb) B.T. Prolongedc) Normal Ristocetin testd) Defective aggregation
Correct Answer: ac
Description: Von Willebrand disease is characterized by the deficiency of vWF, while the synthesis of factor VIIIc is normal.
VWF has two major functions -
Helps in platelet adhesion
Stabilizes factor VIIIc
So, deficiency of vWF results in manifestation of both -
1) Platelet adhesion defect
Bleeding from small venules and capillaries of skin and mucous membrane e.g. epistaxis. a Menorrhagia and GI bleeding
Prolonged bleeding time
2) Coagulation defect (due to factor VIII dysfunction)
Bleeding into weight bearing joints
Large post traumatic ecchymoses or hematoma
Prolonged bleeding after any form of surgical procedure or a laceration.
Prolonged PTT
VWF can be assayed by ristocetin agglutination test which measures the ability of ristocetin to promote the interaction between VWF and platelet membrane glycoprotein Ib-IX.
Category:
Pediatrics
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now