Conjugated hyperbilirubinemia is seen in -a) Rotor’s syndb) Dubin Johnson syndc) Gilbert’s syndd) Breast milk jaundicee) Crigler Najjar syndrome
Correct Answer: ab
Description: Predominantly Unconjugated Hyperbilirubinemia
Excess production of bilirubin
Hemolytic anemias
Resorption of blood from internal hemorrhage (e.g.,alimentary tract bleeding, hematomas)
Ineffective erythropoiesis syndromes (e.g. permicious anemia, thalassemia)
Reduced hepatic uptake
Drug interference with membrane carrier systems
Some cases of Gilbert syndrome
Impaired bilirubin conjugation
Physiologic jaundice of the newborn (decreased UGT1A1 activity,decreased excretion)
Breast milk jaundice (β-glucurondases in milk)
Genetic deficiency of UGT1A1 activity (Crigler-Najjar syndrome types I and II)
Gilbert syndrome (mixed etiologies)
Diffuse hepatocellular disease (e.g. viral or drug-induced hepatitis, cirrhosis)
Predominantly conjugated hyperbilirubinemia
Deficiency of canalicular membrane transponers (Dubin-Johnson syndrome,Rotor syndrome)
Impaired bile flow
Category:
Pathology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now