A 20-year-old patient weighing 60 kg has to be prescribed an antiepileptic drug (available as 200 and 400 mg tablets) for generalized tonic-clonic seizures. The pharmacokinetic parameters and therapeutic plasma concentration of the selected drug are: Target steady-state plasma concentration (Cpss) – 6 mg/L Oral bioavailability (F) – 70% Volume of distribution (V) – 1.4 L/kg Clearance (CL) – 80 ml/hr/kg Plasma half life (t½) – 15 hours What should be the loading dose and the daily maintenance dose of the drug for this patient?
Correct Answer: 720 and 984 mg respectively
Description: The total volume of distribution and total body clearance for this patients has to be calculated first.
Category:
Pharmacology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now