Antihypertensive safe in renal disease is?
Correct Answer: Amlodipine
Description: ANSWER: (B) AmlodipineREF: KDT 6 th edition page 543, 544See APPENDDC- 88 ANTI HYPERTENSIVE MEDICATIONS"Calcium channel blockers are drug of choice for in cyclosporine induced hypertension in renal transplant recipients""The dihydropyridines (DHPs) are the most potent Ca2+ channel blockers. DHPs reduces albuminuria and slows progression in Diabetic nephropathy"Calcium channel blockersPhenyl alkylamine: verapamilBenzothiazepin: DiltiazemDHP; Dihydropyridines: Nifedipine, Felodipine Amlodipine, Nitrendipine, Nimodipine, Lacidipine, Lercanidipine, BenidipineMonotherapy with CCBs is effective in - 50% hypertensives; their action is independent of patient's renin status, and they may improve arterial compliance. Other advantages of CCBs are:Do not compromise haemodynamics: no impairment of physical work capacity.No sedation or other CNS effects; cerebral perfusion is maintained.Not contraindicated in asthma/ angina (especially variant) and PVD patients: may benefit these conditions.Do not impair renal perfusion.Do not affect male sexual function.No deleterious effect on plasma lipid profile, uric acid level and electrolyte balanceShown to have no/minimal effect on quality of life.No adverse foetal effects; can be used during pregnancy (but can weaken uterine contractions during labour).
Category:
Pharmacology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now