A 20 year old male presented with chronic constipation, headache and palpitations. On examination he had marfanoid habitus, neuromas of tongue, medullated corneal nerve fibers and nodule of 2×2 cm size in the left lobe of thyroid gland. This patient is a case of :
Correct Answer: MEN IIB
Description: Answer is D (MEN IIB); The association of medullary carcinoma thyroid & pheochromocytoma, with mucosa' neuromas and marlinoid hahitus is designated 'MEN IIB' - Mucosal neuromas and marlinoid habitus are the most distinctive features of MEN 11B and are recognized in childhood. - Harrison True Neuromas are present on the tip of tongue, under the eyelids and throughout the gastrointestinal tract and are tree neuromas distinct from neurolibromas. MEN I (Wermer's syndrome) MEN II MEN II A (Sipple syndrome) MEN II B Characteristic Manifestations * MTC * MTC * Parathyroid hyperplasia or adenoma * Pheochromocytoma * Pheochromocytoma * Pancreatic tumors (Islet cell hyperplasia, adenoma, or carcinoma) * Parathyroid hyperplasia or adenoma * Mucosal and gastrointestinal neuromas * Marfanoid features * Pituitary hyperplasia or adenoma * Cutaneous lichen amyloidosis Other less common manifestations * Hischsprung disease * Foregut carcinoid * FMTC * Subcutaneous or visceral lipomas * Dermal angiofibromas or collagenomas
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