Amoxicillin + clavulanic acid is active against the following organisms EXCEPT :

A. Methicillin resistant Staph. aureus

B. Penicillinase producing Staph. aureus

C. Penicillinase producing N. gonorrhoeae

D. β-lactamase producing E. coli

Correct Answer: Methicillin resistant Staph. aureus

Description: Staphylococcus aureus develops resistance to methicillin by acquiring altered penicillin-binding proteins that have low affinity. No Beta-lactam antibiotic is effective against MRSA. Clavulanic acid is an inhibitor of β-lactamase. It can restore the sensitivity of penicillins against the organisms who have developed penicillinases.

Category: Pharmacology

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