A 4 year old female child complains of weakness and pain in joints. Her parents are known case of sickle cell trait. Hb electrophoresis reveal HbS pattern. This disease occurs because of which base alteration?
Correct Answer: CTC → CAC in DNA
Description: The occurrence of the disease sickle-cell anemia due to a single base alteration (CTC + CAC in DNA, and GAG + GUG in RNA) is a classical example of the seriousness of mutations.
Satyanarayana- Biochemistry, 3rd edition, pg-549
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Biochemistry
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