All are true about Gilbert’s Syndrome Except –
Correct Answer: Mild conjugated hyper bilirubinemia
Description: Ans-AGilbert syndrome causes unconjugated hyperbilirubinemia.Gilbert's syndrome is an autosomal dominant disorder*.Characteristic features are :*Mild unconjugated hyperbilirubinemia due to:Decreased hepatic uptake of bilirubinDecreased activity of uridyl glucuronyl transferase (causing defective conjugation).*Standard hepatic biochemical tests are normal.*Normal hepatic histology.Gilbert's syndrome is a type of congenital hyperbilirubinemia.Other types of congenital hyperbilirubinemia.*Crigler Najjar* Type I-The complete absence of the enzyme - UDP glucuronyl transferase.Causes severe jaundice, death in early life.Unconjugated hyperbilirubinemia* Type II-* Partial absence of enzyme.Dubin-Johnson-a defect in excretion of conjugated bilirubin, therefore, causes conjugated hyperbilirubinemia.*Rotor's syndrome Same as Dubin-Johnson. Note :The difference between Dubin-Johnson and Rotor's Syndrome.In Dubin-Johnson there is an accumulation of pigment in the hepatocytes, imparting a brown or black color to the liver.Mnemonic - (Michael) Johnson is black
Category:
Unknown
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now