Not true about thalidomide:
Correct Answer: Has no antiangiogenesis action against tumour
Description: Ans. (D) Has no antiangiogenesis action against tumour(Ref: KDT 6/e p84, 834)Thalidomide was banned in 1960 because of its teratogenic effect of phocomelia (seal like limbs). It has anxiolytic, adjuvant analgesic/antipyretic properties and has been found to counteract cancer associated cachexia.Its mechanism of action is by suppressing TNF and or by modulating IL-2.Recently it has been reintroduced as antineoplastic drug due to its anti-angiogenesis action.
Category:
Pharmacology
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