All are true about Hemolytic uremic syndrome except?
Correct Answer: Positive Coombs test
Description: Positive Coombs test is seen with autoimmune hemolytic anemia but in H.U.S microangiopathic hemolytic anemia is seen. The entrapment of platelets in micro-thrombi formed in small blood vessels leads to thrombocytopenia. The consumption of clotting factors due to initiation of coagulation cascade leads to hypofibrinogenemia. Hemolytic uremic syndrome- characterized by the triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure which explains uremia.
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