Bilateral hilar lymphadenopathy with non-caseating granuloma is seen in –
Correct Answer: Sarcoidosis
Description: Sarcoidosis
Sarcoidosis is an immune system disorder characterized by the presence of non-caseating granulomas.
The cause of the disease is still unknown.
Virtually any organ can be affected, however, granulomas most often appear in the lung or the lymph nodes → Bilateral hilar lymphadenopathy or lung involvement is visible on chest radiograph in 90% of cases.
Histology
Histologically involved tissues show the classical non-caseating granulomas, composed of an aggregate of tightly clustered epithelioid cells, often with Langhans or foreign body type giant cells. Central necrosis is unusual → noncaseating.
Granulomas also contain.
i. Schaumann bodies → Laminated concretions composed of calcium and proteins.
ii. Asteroid bodies → Stellate inclusions within giant cells.
Category:
Pathology
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