Which of the following statement is true regarding “Catecholamines” ?

A. Production terminates with dopamine in the brain but epinephrine in the adrenal gland

B. Production begins with the action of tyrosinase on tyrosine

C. Are metabolized to both glucogenic and ketogenic fragments

D. All contain methyl group donated by S-adenosyl methionine

Correct Answer: Production terminates with dopamine in the brain but epinephrine in the adrenal gland

Description: Synthesis of catecholamine is organ specific, so option A is correct. Production of catecholamine begins once tyrosine hydroxylase acts on tyrosine and forms DOPA so option B is wrong. All catecholamine are metabolized to vanillyl mandelic acid (VMA) which gets excreted in urine unchanged. VMA has neither glucogenic nor ketogenic fate. So option C is also wrong. Out of various catecholamine, only epinephrine has got one methyl group. Dopamine and norepinephrine does not contain any methyl group. So option D is also wrong.

Category: Unknown

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