Neutrophilic leukocytosis, lymphopenia, and eosinopenia are most likely associated with which of the following disorders?
Correct Answer: Cushing syndrome
Description: Neutrophilic leukocytosis, lymphopenia, and eosinopenia are most likely associated with Cushing syndrome and the hypercoisolism associated with the syndrome. Coisol decreases neutrophil adhesion in the peripheral blood, thus releasing the marginating pool into the circulation. Coisol also increases lymphocyte adhesion in the efferent lymphatics and is toxic to eosinophils. Endotoxic shock results in a neutropenia because endotoxins increase neutrophil adhesion. Absolute neutropenia is a feature of typhoid fever, splenomegaly, and sinus bradycardia. Whooping cough due to Bordetella peussis produces an absolute lymphocytosis. Paroxysmal nocturnal hemoglobinuria, an acquired stem-cell disorder with increased sensitivity of hematopoietic cells to complement destruction, is associated with aplastic anemia and pancytopenia. Ref - Harrison's principles of internal medicine 20e pg 2680-2681, 2681t, 2724-2725
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