The basis of combining ritonavir with lopinavir is ?
Correct Answer: CyP3A4 inhibition by ritonavir
Description: Ans. is 'b' i.e., CyP3A4 inhibition by ritonavir o Ritonavir is a potent inhibitor of CyP3A4, as such, co-administration with agents heavily metabolized by CyP3A4 must be approached with caution. o This propey of ritonavir can be exploited as a benefit also. o Other less toxic proton pump inhibitors (lopinavir, indinavir, amprenavir) are also metabolized by CyP3A4. So, if lower than therapeutic dose of ritonavir is given along with any of these PIs, it inhibits the metabolism of these drugs. o This results in following benefits for these PIs (lopinavir, indinavir, amprenavir): i) Increased time of drug exposure --> reduced risk of resistance ii) Prolonged half life and less frequent dosing ---> increased compliance.
Category:
Pharmacology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now