Angiodema is seen due to deficiency of?
Correct Answer: C1 esterase inhibitor
Description: Ans. is 'b' i.e., Cl esterase inhibitor Angioedema (angiooedema/ Quincke's edema/ angioneurotic edema)o Characterized by rapid swelling (edema) of the dermis, subcutaneous tissue, mucosa and submucosal tissues. It is very similar to urticaria, but urticaria, commonly known as hives, occurs in the upper dermiso Angioedema is classified as either hereditary or acquired.a) Acquired angioedema (AAE) can be immunologic, nonimmunologic, or idiopathic. It is usually caused by allergy and occurs together with other allergic symptoms and urticaria. It can also occur as a side effect to certain medications, particularly ACE inhibitors.b) Hereditary angioedema (HAE) exists in three forms, all of which are caused by a genetic mutation inherited in an autosomal dominant form.i) Types I and II are caused by mutations in the SERPINGl gene, which result in either diminished levels of the Cl-esterase inhibitor protein (type I HAE) or dysfunctional forms of the same protein (type II HAE).ii) Type III HAE has been linked with mutations in the F12 gene, which encodes the coagulation protein factor XII.o All forms of HAE lead to abnormal activation of the complement system.o The end product of this cascade, bradykinin, is produced in large amounts and is believed to be the predominant mediator leading to increased vascular permeability and vasodilation that induces typical angioedema "attacks".
Category:
Pathology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now