A 60-year-old male patient presented to OPD with right upper quadrant abdominal pain, jaundice, fever with a significant history of weight loss, loss of appetite and lethargy. On examination a mass was palpable in the right hypochondrium which was firm in consistency and about 5×5 cm on palpation along with severe hepatomegaly. On seeing the previous records, patient was found to be a known case of Hepatitis C and was on medication for the same. Lab studies, Raised AFP levels Hypercalcemia Erythrocytosis No cirrhotic changes were evident on USG abdomen. Triple phase CT, Liver biopsy were performed. . Which of the following drug has been approved for the above condition: – Sorafenib Imatinib Dasatinib Regorafenib Ramucirumab
Correct Answer: 1, 4 and 5
Description: This is a case of hepatocellular carcinoma. HPE image shows malignant hepatocytes growing in distoed versions of normal architecture. The aerial phase in triple phase CT shows a large enhancing lesion suggestive of hepatocellular carcinoma. Imatinib and Dasatinib are tyrosine kinase inhibitors approved for CML.
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