All of the following features about generalized (diffuse) systemic sclerosis are true, Except:
Correct Answer: Anti centromere antibodies are characteristic
Description: Answer is C (Anticentromere antibodies are characteristic): Antitopoisomerase antibodies (Scl 70) are characteristic of diffuse systemic sclerosis and not Anticentromere antibodies. Subsets of systemic sclerosis (SSC): Limited cutaneous SSC versus diffuse cutaneous: Features Limited cutaneous SSc Diffuse cutaneous SSc Skin involvement Limited to fingers, distal to elbows, face; slow progression Diffuse: finger, extremities, face, trunk; rapid progression Raynaud's phenomenon Preceds skin involvement; associated with critical ischemia Onset contemporaneous with skin involvement Pulmonary fibrosis May occur, moderate Frequent, early and severe Pulmonary aerial hypeension Frequent, late, may be isolated May occur, associated with pulmonary fibrosis Scleroderma renal crisis Very rare Occurs in 15%; early Calcinosis cutis Frequent, prominent May occur, mild Characteristic autoantibodies Anticentromere Antitopoisomerase (Scl - 70) Systemic symptoms Infrequent systemic symptoms such as Ahralgias, weight loss and pulmonary symptoms Significant systemic symptoms such as Ahralgias, weight loss and tendon friction rubs
Category:
Medicine
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now