Which of the following antitumor agents works by impairing de novo purine synthesis?
Correct Answer: Methotrexate (antifolate)
Description: Among the given antitumor drugs, methotrexate which is folic acid analog act as a folate antagonist that inhibit the conversion of (DHFA)Dihydro folic acid to tetra hydrofolic acid (THFA). We know that follic acid is utilized in de novo synthesis. Where as 5-fluorouracil act as pyrimidine antagonist by inhibiting the conversion of deoxyuridine acid to deoxythymidylic acid. And Allopurinol act by inhibiting uric acid synthesis. ESSENTIALS OF MEDICAL PHARMACOLOGY-SEVENTH EDITION -K.D TRIPATHI Page:864,862,216
Category:
Pharmacology
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