A 40-year-old male presented with symptoms of anemia along with weight loss, night sweats, and low-grade fever.On examination, splenomegaly, petechiae, ecchymosis, lymphadenopathy was noted along with some features of poal hypeension.Lab findings revealed anemia, leukocytosis and thrombocytosis. Bone marrow aspiration reveals a dry tap. Bone marrow biopsy was taken and subjected to reticulin staining.. All of the following genes can be mutated in the above condition except: –
Correct Answer: ACTN3
Description: This is a case of primary myelofibrosis. Primary myelofibrosis. Peripheral smear shows teardrop red blood cells (RBCs) and a leukoerythroblastic picture with nucleated RBC precursors and immature myeloid cells. Bone marrow biopsy from a patient with primary myelofibrosis shows extensive fibrosis which is confirmed by reticulin staining. Mutations in the JAK2, MPL, CALR, and TET2 genes are associated with most cases of primary myelofibrosis.
Category:
Unknown
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now