Both loop diuretics and thiazides can cause hypokalemia by:
Correct Answer: Increasing the availability of Na+in the distal tubular fluid to exchange with interstitial K+
Description: Diuretics prevent the reabsorption of Na+-more amount of Na+ reaches the distal poion of the nephron i.e. late DT and collecting ducts. Na+ is exchanged with K+ and H+ Increased distal delivery of Na+ results in more exchange and thus hypokalemia
Category:
Pharmacology
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