Phosphaturia is seen in the following except
Correct Answer: Metabolic alkalosis
Description: Metabolic alkalosis decrease serum phosphorus concentration.Hypophosphatemia secondary to phosphorus redistribution is commonly caused by respiratory alkalosis and refeeding of malnourished patients.Acute respiratory alkalosis and metabolic alkalosis decrease serum phosphorus concentration. The reduction is much greater in respiratory alkalosis than in metabolic alkalosis of comparable severity. During respiratory alkalosis, intracellular CO2decreases, causing intracellular pH to rise.This mechanism stimulates the glycolytic pathway, specifically phosphofructokinase, a key rate-limiting enzyme of glycolysis. Production of sugar phosphates is enhanced, which in turn induces intracellular phosphorus entry, thus decreasing serum phosphorus concentration.Alkalosis enhances phosphorus uptake by muscle. The kidney responds by increasing phosphate reabsorption, independent of serum phosphorus concentration and becomes refractory to the phosphaturic effect of PTH.Ref: DM Vasudevan, 7th edition, page no: 402, 403
Category:
Biochemistry
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