Amyloid-rich stroma was seen on H&E stain of a thyroid nodule as shown below. What would be the diagnosis?
Correct Answer: Medullary thyroid carcinoma
Description: Medullary Carcinoma of thyroid (MCT) Arise form para follicular 'C' Cells Derived from - Ultimobranchial bodies Secretes - calcitonin Level of calcitonin is raised Level of calcium is normal Clinical Features Midline swelling in anterior pa of neck Characteristic features Raised calcitonin History of diarrhea Presence of amyloid stroma Positive family history of Pheochromocytoma & Hyperparathyroidism (due to association with MEN 2A & MEN 2B)
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