The presence of a noncompetitive inhibitor can be implicated in which of the outcome?

A. Leads to both an increase in the Vmax of a reaction and an increase in the Km

B. Leads to a decrease in the observed Vmax

C. Leads to a decrease in Km and Vmax

D. Leads to an increase in Km without affecting Vmax

Correct Answer: Leads to a decrease in the observed Vmax

Description: In the presence of a noncompetitive inhibitor, Vmax is decreased, whereas Km is unchanged. The steady-state concentration of ES is decreased.

Category: Biochemistry

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