Which is true hermaphroditism?
Correct Answer: 46XX/46XY
Description: Ref. The Short Textbook of Pediatrics. Pg 749
Hermaphroditism
True’ hermaphroditism is a genetic condition in which affected individuals have both mature ovarian and testicular tissue. The entity is due to chromosomal and genetic cause .
Both the testis and the ovarian tissue are present in an individual and in different combinations .
Ovotestis on each side (commonest)
Testis on one side ,ovary on other .
Testis or ovary on one side and ovotestis on the other .
It is probable that fertilisation by a sperm carrying one X chromosome , which contains some male determinant material from Y gives rise to this condition .
The common presentation is ambiguity of external genitalia .
The internal structure depends on the degree of differentiation of associated gonad on that side .
75% develop gynecomastia and nearly 50% menstruate
INVESTIGATIONS :
Sex chromatin is usually positive
Karyotype is usually 46 XX(70%) ,rest are 46 XY and rarely mosaic XX/XY
Confirmation is done by gonadal biopsy
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