Eternacept acts by one of the following mechanisms?
Correct Answer: By blocking tumor necrosis factor
Description: Ans is 'a' i.e., By blocking tumor necrosis factor BIOLOGIC RESPONSE MODIFIER (BRMs1 o Several recombinant proteins/monoclonal antibodies that bind and inhibit cytokines, especially TNFa or IL-I have been used succesfully in autoimmune diseases like RA, IBD, psoriosis or scleroderma. A. TNF-a inhibitors a. Etanercept o It is a recombinant fusion protein of TNF - receptor and Fc poion of human IgG1. o It is administered by S.C. injection. b.Infliximab o It is a chimeral monoclonol antibody which binds and neutralizes TNF-alpha. o It is given by i.v. route. o It is indicated in RA, psoriotic ahritis, Crohn's disease, Wegener's granulomatosis and sarcoidosis. c. Adalimumab o This recombinant monoclonal anti-TNF antibody. o It is administered by S.C. route. B. IL,-1 antagonist Anakinra o It is a recombinant human IL-I receptor antagonist. o It is less effective than TNF inhibitors. o It is administered by S.C. route. C. T-cell costimulatory blockers Abatacept o It is a fusion protein that combines the extracellular domain of the molecule CTLA4 (CD 154) with the Fe poion of a human immunoglobulin. o It interfere with the interactions between antigen presenting cells and T lymphocytes. Therefore, it affects early stages in the pathogenic cascade of event in RA. D. B-cell depicters Rituxintab o B-cells are inflammatory cells with multiple functions in the immune response. The depletion of B cells has been shown to be effective in reducing signs and symptoms of RA and in slowing radiographic progression. o Rituximab is a chimeric monoclonal antibody that binds to the CD20 molecule on the B cell surface leading to the removal of B cells from the circulation.
Category:
Pharmacology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now