HbsAg positive person can have following association/s –
Correct Answer: Membraneous glomerulonephritis
Description: The hepatitis B virus (HBV) has a complex relationship to kidney diseases. Chronic HBV infection is an etiologic factor in secondary glomerular diseases. From an opposite perspective, the HBV carrier status has a critical impact on the clinical management of kidney transplant recipients and patients with renal diseases who are treated with immunosuppressive drugs. HBV is not directly cytopathic to hepatocytes. The host immune response, especially virus-specific cytotoxic T lymphocytes, is the basis for hepatocellular damage as well as viral clearance. Neonatal exposure to HBV when the immune system is immature results in minimal acute hepatitis, but this is followed by chronic infection in 90% of subjects, and contributes to the bulk of chronic HBV carriers. After entering hepatocytes by endocytosis, the paially double-stranded viral genomic DNA is transpoed into the nucleus, where it is conveed to covalently closed circular DNA, which serves as a template for transcription of viral mRNAs, which in turn are used for viral replication through reverse transcription and the production of viral DNA polymerase and other viral proteins. Intrahepatic covalently closed circular DNA thus accounts for the persistence of infection. About 350 million people worldwide have chronic HBV infection Ref Davidson edition23rd pg876
Category:
Medicine
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now