McArdle’s disease is due to deficiency of ?
Correct Answer: Muscle phosphorylase
Description: Muscle phosphorylase [Ref Harper 250/e p. 181Type Enzyme deficiencyOrgan (s) affected von Gierke's diseaseGlucose 6-phosphataseLiver, kidneyIIPompe's diseasea (1 4) Glucosidase (acid maltase)All organsIIICori's disease/Forbe's diseaseDebranching enzymeMuscle, liverIVAndersen's diseaseBranching enzymeLiver, myocardiumVMcArdle's diseasePhosphorylaseMuscleVIHers' diseasePhosphorylaseLiverVIITarui's diseasePhosphofructokinaseMuscle, RBCsVIII Phosphorylase kinaseLiverThere is also on X-linked form of phosphorylase kinase deficiency. This is sole exception as all other glycogen storage diseases are inherited as autosomal recessive trait.
Category:
Biochemistry
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