Aplastic anemia can progress to -a) AMLb) Myelodysplastic anemiac) Pure red cell aplasiad) Paroxysmal nocturnal hemoglobinuriae) Myelofibrosis
Correct Answer: abd
Description: Aplastic anemia is a pancytopenia with bone marrow hypocellularity. It can progress to –
Paroxysmal Nocturnal hemoglobinuria
Myelodysplastic anemia
Rarely acute leukemia
Pure red cell aplasia is a selective disease of absence of erythrocyte progenitor cells. In contrast to aplastic anemia and MDS, the unaffected lineage (WBC and platelets) appear quantitatively and qualitatively normal.
Myelofibrosis is a clonal disorder of a multipotent hematopoietic progenitor cell of unknown origin and is characterized by
Marrow fibrosis
Myeloid metaplasia with extramedullary erythropoiesis
Splenomegaly
Category:
Pathology
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