About SUPERANTIGENS true is
Correct Answer: Directly attached to latrel aspect of TCR beta chain
Description: Super antigens are molecules that can interact with antigen-presenting cells (APCs) and T-lymphocytes in a non-specific manner.
These antigens do not involve the endocytic processing as required in typical antigen presentation.
Interaction of superantigens with MHC class II molecules of the APC and the V~ domain of the T-lymphocytes receptor activates a large number of T-lymphocytes than conventional antigens.
This leads to massive cytokine expression and immuno-modulation.
Staphylococcal enterotoxins, exfoliative toxin and some viral proteins are examples of superantigens.
Ref : textbook of microbiology, C P Baveja 5th edition pg no:95
Category:
Microbiology
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