CD59 deficiency leads to:

Correct Answer: PNH
Description: Ref. Robbins Pathology. 9th edition. Page. 642 PNH : Defect in GPI linked proteins  - CD55 and CD 59 Mutation in PIGA gene Intravascular hemolysis Triad – IV hemolysis, Thrombosis, Pancytopenia Can result in AML Diagnostic methods HAM test – no more used Gel card test Flow cytometry – IOC Best – FLAER (Fluorescent Aerolysin test)
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