Which of the following virus produces punched out ulcer in the esophagus and biopsy demonstrate multinucleated epithelial cells with intranuclear inclusions at the margin of ulcer?
Correct Answer: Herpes simplex virus (HSV)
Description: Various ulcers: Virus Herpes simplex virus Cytomegalovirus (CMV) Endoscopy Punched-out ulcers Shallow ulcerations Biopsy Diagnostic Cowdry A inclusions and multinucleated cells with nuclear molding and ground glass nuclei within a rim of degenerating epithelial cells at the margin of the ulcer. Cytomegalic cells, typically 2-4 fold larger than normal, containing basophilic cytoplasmic & intranuclear inclusion bodies surrounded by a clear halo, giving the appearance of an owl's eye within capillary endothelium & stromal cells Microscopic
Category:
Pathology
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