Vitamin C is necessary in the formation of collagen. It is required for the conversion of:
Correct Answer: Proline to hydroxyproline
Description: Ans. (a) Proline to hydroxyprolineRef: Harpers Biochemistry, 30th ed. pg. 47, 562* Ascorbic acid is needed for a variety of biosynthetic pathways, by accelerating hydroxylation and amidation reactions.* In the synthesis of collagen, ascorbic acid is required as a cofactor for following enzymes:# Prolyl hydroxylase# Lysyl hydroxylase* These two enzymes are responsible for the hydroxylation of the proline and lysine amino acids in collagen.* Remember, Hydroxyproline and hydroxylysine are important for stabilizing collagen by cross-linking the propeptides in collagen.* Clinical effects if there is defective collagen fibrillogenesis:# Impaired wound healing.# Impaired bone bormation# Abnormal bleeding due to fragile capillaries.
Category:
Biochemistry
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now