Which of the following pathogenic mechanism is involved in the generation of sarcoidosis:
Correct Answer: All of the above
Description: Pathogenesis of sarcoidosis: Unidentified antigen - CD4+ helper T cells - Non-necrotizing epithelioid granuloma Intra-alveolar and interstitial accumulation of CD4+ helper T-cells. Increase in Th1 cytokines such as IL-2 and IFN-g, resulting in T cell proliferation and macrophage activation, respectively Increase in several cytokines in the local environment (IL-8, TNF, macrophage inflammatory protein-1a) that or recruitment of additional T cells and monocytes and contribute to the formation of granulomas. Significant elevation of angiotensin-conveing enzyme (ACE) in serum (derived from activated macrophages. Impaired dendritic cell function.
Category:
Pathology
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