Mikulicz cells and Russell bodies are seen in
Correct Answer: Rhinoscleroma
Description: Rhinoscleroma # Chronic granulomatous infection of nose and upper respiratory tract # Affects adults, mainly in tropical locations # Transmitted by inhalation of Klebsiella rhinoscleromatis # a/w cellular immune defects: inability of macrophages to kill phagocytosed bacteria - Mikulicz cells (large, vacuolated histiocytes containing bacteria) # Three clinical phases: * Catarrhal phase (rhinitis, obstruction from soft tissue edema) * Granulomatous/infiltrative phase (granulomatous nodules in nose/U, epistaxis, dysphonia, anesthesia of soft palate, and Hebra nose) * Sclerotic phase (extensive scarring requires tracheotomy and nasal reconstruction) Histology:- Dense pan-dermal infiltrate of Mikulicz cells containing bacteria (seen w/ Wahin-Starry, Giemsa) and Russell bodies Treatment:- Tetracycline(treatment of choice) for 6 months along with surgical correction of airway; ciprofloxacin is second line. Above picture shows RUSSELL Bodies Ref:- Review of Dermatology by Alikhan; pg num:-299
Category:
Dental
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now