Familial hypercholesterolemia is associated with
Correct Answer: Premature atherosclerosis
Description: A positive correlation exists between the incidence of atherosclerosis and the plasma concentration of LDL cholesterol. The LDL (apoB-100, E) receptor is defective in familial hypercholesterolemia, a genetic condition which blood LDL cholesterol levels are increased, causing premature atherosclerosis.Ref: Harper&;s Biochemistry; 30th edition; Chapter 25; Lipid Transpo & Storage
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Biochemistry
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