Which of the following is involved in peristalsis by causing relaxation

Correct Answer: Vasoactive Intestinal Polypeptide
Description: The release of NO and VIP (Vasoactive intestinal polypeptide) from the cholinergic neurons passing in an anterograde direction relaxes the segment of the intestine ahead of the stimulus. Peristalsis involves the contraction of a segment of intestine behind the bolus of food and relaxation of a segment behind the bolus of food and relaxation of a segment of the intestine in front of the bolus of food. Cholinergic neurons passing in retrograde direction produce substance P and acetylcholine which cause contraction of a segment of intestine. Cholinergic neurons passing in anterograde direction produce NO and VIp which causes relaxation of a segment of the intestine in front of a bolus of food. Ref: Ganong&;s Review of medical physiology 26th edition Pgno: 495
Category: Physiology
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