Antibiotic that interferes with DNA function is:
Correct Answer: Metronidazole
Description: Mechanism of Action
Metronidazole is a prodrug requiring reductive activation of the nitro group by susceptible organisms.
Unlike their aerobic counterparts, anaerobic and microaerophilic pathogens contain electron transport components that have a sufficiently negative redox potential to donate electrons to metronidazole.
The single-electron transfer forms a highly reactive nitro radical anion that kills susceptible organisms by radical-mediated mechanisms that target DNA.
Reference: Goodman & Gilman’s THE PHARMACOLOGICAL BASIS OF THERAPEUTICS THIRTEENTH EDITION
Page no 991
Category:
Pharmacology
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