Medical MCQ-A parent is homozygous and a parent heterozygous for an autosomal recessive gene. What will be the outcome –

A parent is homozygous and a parent heterozygous for an autosomal recessive gene. What will be the outcome –

75% children affected

No child affected, but all are carriers

50% children affected, rest are carriers

25% children affected, rest are carriers

Question Category:

Pediatrics

Correct Answer:

50% children affected, rest are carriers

Description:

Autosomal recessive disordersAutosomal recessive disorders are manifested in homozygous state, i.e. when both alleles at a given gene locus are mutant. There may be following five situations -

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