In a 30 years old female patient with polyahritis, testing reveals nucleolar pattern of ANA staining. What is the likely course of this patient?
Correct Answer: Sclerodactyly, esophageal dysmotility and Raynaud's phenomenon
Description: Answer- B. Sclerodactyly, esophageal dysmotility and Raynaud's phenomenonNucleolsr ANA positivity is most likely suggestive of systemic sclerosis or scleroderma, which comprises of diffuse or limited disease-CREST syndrome (Calcinosis, Raynaud syndrome, Esophageal dysmotility, Sclerodactyly, Telangiectasia)Antinuclear antibodies are directed against nuclear antigens, grouped into: ( I ) antibodies to DNA (2) antibodies to histones (3) antibodies to non-histone proteins bound to RNA (4) antibodies to nucleolar antigens.Most widely used method for detecting ANAs: Indirect immunoffuorescence (identify antibodies that bind to a variety of nuclear antigens, including DNA, RNA & proteins).Pattern of nuclear fluorescence suggests the type of antibody present in the patient's serum.
Category:
Pathology
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