A new marker for mantle cell lymphoma especially useful in Cyclin DI negative cases is:
Correct Answer: SOX 11
Description: Answer- A. SOX 11SOXII expression h a highly specific for mantle cetl lymphoma and identifies the cyclin Dl-negative subtype.Mantle Cell Lymphoma (MCL)Immunophenotype:CD20 CD79a & PAX-5 positive establish B lineageCD5, CD43, FMC-7, cyclin Dl & SOX11 positiveSurface IgM & IgD positiveCDS+ve & CD23 -ve which help to distinguish it from CLL/SLL.
Category:
Pathology
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